Regulation of the PKD2 channel function and associated disease phenotypes by RASSF4
Rui Tian, Wanyi Fang, Wenbin Yuan, Shi Li, Yixin Wu, Xueying Dong, Wei Liu, Jinghua Kong, Xiaoling Deng, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Declan William Ali, Marek Michalak, Cefan Zhou, Jingfeng Tang, Xing-Zhen Chen · 2026
Read Regulation of the PKD2 channel function and associated disease phenotypes by RASSF4 by Rui Tian, Wanyi Fang, Wenbin Yuan, Shi Li, Yixin Wu, Xueying Dong, Wei Liu, Jinghua Kong, Xiaoling Deng, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Declan William Ali, Marek Michalak, Cefan Zhou, Jingfeng Tang, Xing-Zhen Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13434659.txt.
Description
Rui Tian led a large team studying a kidney disease protein in a 2026 paper. The disease is a common inherited cause of kidney cysts, driven by faults in one of two proteins. Treatments are limited, so regulators of the channel protein matter. Using a tagging method in human kidney cells, they found a new partner protein that binds it.
Several tests confirmed the pairing in cells and mouse kidneys. The partner boosts the channel's activity without changing how much reaches the cell surface. In fish larvae, extra partner eased the harm from losing the channel, while losing the partner made it worse. A blocking fragment broke the benefit. The pair is proposed as a drug target.
Catalog record
| CREATOR | Rui Tian, Wanyi Fang, Wenbin Yuan, Shi Li, Yixin Wu, Xueying Dong, Wei Liu, Jinghua Kong, Xiaoling Deng, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Declan William Ali, Marek Michalak, Cefan Zhou, Jingfeng Tang, Xing-Zhen Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |