Practical and divergent electrochemical access to thiocarbamoyl fluorides and N-trifluoromethyl amines from secondary amines
Feba T Pulikkottil, Daniel F Carvalho, Kohei Taniguchi, John S Burnett, Charles A I Goodall, Victoria K Elmes, Andrew Hurt, Ewan R Clark, Anthony J H M Meijer, Kevin Lam · 2026
Read Practical and divergent electrochemical access to thiocarbamoyl fluorides and N-trifluoromethyl amines from secondary amines by Feba T Pulikkottil, Daniel F Carvalho, Kohei Taniguchi, John S Burnett, Charles A I Goodall, Victoria K Elmes, Andrew Hurt, Ewan R Clark, Anthony J H M Meijer, Kevin Lam (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13434417.txt.
Description
Feba T Pulikkottil and coauthors use electric current to turn simple amines into prized fluorine compounds in 2026. Two product families come from one pot setup with cheap, shelf stable stock. No dry solvents, no inert gas, and no costly silver agents are needed.
Shifting the mix steers the pot toward one family or the other. Yields range from fair to excellent across many starting amines. Late changes to complex drug like molecules also worked. Tests with voltage scans and spectra support a path through sulfur rich steps before fluorine enters. The bench friendly route should suit scale up.
Catalog record
| CREATOR | Feba T Pulikkottil, Daniel F Carvalho, Kohei Taniguchi, John S Burnett, Charles A I Goodall, Victoria K Elmes, Andrew Hurt, Ewan R Clark, Anthony J H M Meijer, Kevin Lam |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43922 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |