Recurrent intra-tumour heterogeneity is a hallmark of metastatic prostate cancer
Sirui Weng, Lachlan Cain, James Comben, Yangyi Zhang, Timothy Semple, Sara Alaei, David Yoannidis, Luciano Martelotto, Catherine Mitchell, Anupama Pasam, Richard J. Young, Benjamin Blyth, Joy Hendley, Yuzhou Feng, Heather Thorne, Roslyn Wallace, Joanna Chan, Julia Como, Lisa Devereux, Himisha Beltran, Daniel Wetterskog, Scott Williams, Anthony T. Papenfuss, Belinda Parker, Paul Neeson, Gerhardt Attard, David Quigley, David L. Goode, Richard B. Pearson, Luc Furic, Anna S. Trigos, Shahneen Sandhu · 2026
Read Recurrent intra-tumour heterogeneity is a hallmark of metastatic prostate cancer by Sirui Weng, Lachlan Cain, James Comben, Yangyi Zhang, Timothy Semple, Sara Alaei, David Yoannidis, Luciano Martelotto, Catherine Mitchell, Anupama Pasam, Richard J. Young, Benjamin Blyth, Joy Hendley, Yuzhou Feng, Heather Thorne, Roslyn Wallace, Joanna Chan, Julia Como, Lisa Devereux, Himisha Beltran, Daniel Wetterskog, Scott Williams, Anthony T. Papenfuss, Belinda Parker, Paul Neeson, Gerhardt Attard, David Quigley, David L. Goode, Richard B. Pearson, Luc Furic, Anna S. Trigos, Shahneen Sandhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13434311.txt.
Description
Sirui Weng and colleagues profile late stage prostate cancer that has spread in 2026. Tissue came from 34 spread sites in nine men, taken at rapid autopsy. Single cell gene reads and full genome reads were paired for each site.
Spread tumors held mixed cell groups, yet the same working groups kept turning up across sites and men. The cell mix near a tumor did not seem to drive most of that pattern. Gene changes from cell lineage drove wide shifts but rarely made new working states. Shared pressure across the body may force the same mix, which gives drug teams common targets.
Catalog record
| CREATOR | Sirui Weng, Lachlan Cain, James Comben, Yangyi Zhang, Timothy Semple, Sara Alaei, David Yoannidis, Luciano Martelotto, Catherine Mitchell, Anupama Pasam, Richard J. Young, Benjamin Blyth, Joy Hendley, Yuzhou Feng, Heather Thorne, Roslyn Wallace, Joanna Chan, Julia Como, Lisa Devereux, Himisha Beltran, Daniel Wetterskog, Scott Williams, Anthony T. Papenfuss, Belinda Parker, Paul Neeson, Gerhardt Attard, David Quigley, David L. Goode, Richard B. Pearson, Luc Furic, Anna S. Trigos, Shahneen Sandhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 107902 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |