Lateral septum GABAergic neurons mediate the effects of dexmedetomidine on allodynia and sleep in a male mouse model of neuropathic pain
Haiting Fan, Yingying Su, Jie Deng, Zhengkai Liang, Meiying Chen, Kaibin Wu, Peiwen Tang, Chen Wang, Deyi Kong, Ting Xu, Feixue Liang, Wenjun Xin, Yan Wu, Xia Feng · 2026
Read Lateral septum GABAergic neurons mediate the effects of dexmedetomidine on allodynia and sleep in a male mouse model of neuropathic pain by Haiting Fan, Yingying Su, Jie Deng, Zhengkai Liang, Meiying Chen, Kaibin Wu, Peiwen Tang, Chen Wang, Deyi Kong, Ting Xu, Feixue Liang, Wenjun Xin, Yan Wu, Xia Feng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13434266.txt.
Description
Haiting Fan and colleagues link poor sleep and lasting pain to one brain cell group in male mice in 2026. Nerve harm raised activity in quieting cells of the lateral septum, a small midbrain area. Both pain response to touch and broken sleep rose with that activity.
A sedative drug calmed those cells through a known receptor and eased both pain and sleep loss. The septum cells send branches to a sleep area, with two paths split by job. One path shaped touch pain and the other shaped sleep. The shared circuit gives drug makers a single target for two linked problems.
Catalog record
| CREATOR | Haiting Fan, Yingying Su, Jie Deng, Zhengkai Liang, Meiying Chen, Kaibin Wu, Peiwen Tang, Chen Wang, Deyi Kong, Ting Xu, Feixue Liang, Wenjun Xin, Yan Wu, Xia Feng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74198 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |