Structural basis for LMBD1-dependent trafficking and cobalamin export of ABCD4
Qiwei Liu, Xingfan Li, Yingjie Wu, Kai Zheng, Mi Zhou, Tao Long · 2026
Read Structural basis for LMBD1-dependent trafficking and cobalamin export of ABCD4 by Qiwei Liu, Xingfan Li, Yingjie Wu, Kai Zheng, Mi Zhou, Tao Long (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13434180.txt.
Description
Qiwei Liu and coauthors explain in 2026 how a helper protein moves a vitamin B12 exporter to the right place in the cell. The exporter, ABCD4, needs the helper LMBD1 to reach the lysosome, the cell part that breaks down waste. Faults in either protein cause rare illness tied to B12 use.
Cryo electron images show the pair in three states, with and without cargo. The helper has nine segments that cross the cell film and a tail that grips the exporter. Cell tests show that breaking the grip keeps the exporter from its post. The maps clarify how B12 is held and moved.
Catalog record
| CREATOR | Qiwei Liu, Xingfan Li, Yingjie Wu, Kai Zheng, Mi Zhou, Tao Long |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52422 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |