Scaling covalent ligand discovery through dynamic combinatorial library-versus-proteome screening
Yuchen Huang, Lexuan Hou, Ruiping He, Lin Zhu, Caifeng Xu, Shixiang Duan, Jing Hu, Xi Yang, Yu-Hsuan Tsai, Chu Wang, Chunmao He, Xiaoyu Li, Li Chen, Gang Li · 2026
Read Scaling covalent ligand discovery through dynamic combinatorial library-versus-proteome screening by Yuchen Huang, Lexuan Hou, Ruiping He, Lin Zhu, Caifeng Xu, Shixiang Duan, Jing Hu, Xi Yang, Yu-Hsuan Tsai, Chu Wang, Chunmao He, Xiaoyu Li, Li Chen, Gang Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13434135.txt.
Description
Yuchen Huang and colleagues describe a 2026 screen that tests whole sets of drug like compounds against many proteins at once. Older screens test one compound at a time and need each compound made in advance. Their mix and test plan lets proteins pick out the best fit before full synthesis.
The team found blockers for three enzymes and mapped more than 2,600 sites on proteins that new drugs could target. Work on one protein, VCP, led to a strong blocker that slowed tumors in animals. A fast gel test checked more than 800 variants in two days. The plan raises screening speed ten to twenty fold.
Catalog record
| CREATOR | Yuchen Huang, Lexuan Hou, Ruiping He, Lin Zhu, Caifeng Xu, Shixiang Duan, Jing Hu, Xi Yang, Yu-Hsuan Tsai, Chu Wang, Chunmao He, Xiaoyu Li, Li Chen, Gang Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 112107 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |