Sulfonyl-PYBOX/ErCl3 complex enable highly enantioselective synthesis of α,α-dialkyl and α-alkyl-α-aryl hydrazinonitriles
Yi Gong, Zheng Zhang, Qiang Cao, Cai Wang, Min-Chuan Jiang, Zhi-Heng Qiu, Xiao-Jing Le, Yu-Jie Ye, Tao Wang, Yun-Hao Tang, Ying Zhang, Haoran Zhao, Li Cui, Feng Zhou, Bo-Shuai Mu, Xin Wang, Jian Zhou · 2026
Read Sulfonyl-PYBOX/ErCl3 complex enable highly enantioselective synthesis of α,α-dialkyl and α-alkyl-α-aryl hydrazinonitriles by Yi Gong, Zheng Zhang, Qiang Cao, Cai Wang, Min-Chuan Jiang, Zhi-Heng Qiu, Xiao-Jing Le, Yu-Jie Ye, Tao Wang, Yun-Hao Tang, Ying Zhang, Haoran Zhao, Li Cui, Feng Zhou, Bo-Shuai Mu, Xin Wang, Jian Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13434049.txt.
Description
Yi Gong and co-authors found a rare-earth catalyst pair in 2026 that adds cyanide to ketone kin with near-perfect hand pick, opening a short road to a famed brain drug. Twin-armed end products of this kind anchor drugs and farm sprays. Yet face pick across wide stock has fought chemists for years. The two arms on the start carbon look near alike.
A tight ligand with a sulfur cap steers the rare-earth heart. Both fat and ring ketone starts gave end goods at top hand purity. The route reached the brain drug in four steps at a fat overall yield, the shortest such path yet. One end good killed cotton aphids at a dose on par with shop sprays.
Catalog record
| CREATOR | Yi Gong, Zheng Zhang, Qiang Cao, Cai Wang, Min-Chuan Jiang, Zhi-Heng Qiu, Xiao-Jing Le, Yu-Jie Ye, Tao Wang, Yun-Hao Tang, Ying Zhang, Haoran Zhao, Li Cui, Feng Zhou, Bo-Shuai Mu, Xin Wang, Jian Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41303 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |