Exosomal integrin αvβ3 derived from colorectal cancer promotes the liver pre-metastatic niche formation by inducing cancer-associated fibroblasts activation
Jing Yu, Jiangning Xiang, Lin Yao, Shan Wang, Yifan Liu, Enli Chen, Xiaolin Liu, JinXiang Wu, Yuhao Wang, Lei Zhao · 2026
Read Exosomal integrin αvβ3 derived from colorectal cancer promotes the liver pre-metastatic niche formation by inducing cancer-associated fibroblasts activation by Jing Yu, Jiangning Xiang, Lin Yao, Shan Wang, Yifan Liu, Enli Chen, Xiaolin Liu, JinXiang Wu, Yuhao Wang, Lei Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13433584.txt.
Description
Jing Yu and colleagues trace how bowel cancer primes the liver for spread, using tiny tumour sacs that carry a sticky protein called integrin alpha-v beta-3. Liver spread needs a pre-set niche, and liver star cells can turn into scar-like fibroblasts that build it, yet the spark was not clear.
The sticky protein tracked with liver spread and poor outlook, and tumour sacs that bore it homed to star cells through fibronectin and switched them on. Switch-on ran through the MEK-ERK signal path via a vitronectin-protein-FAK chain. Once turned to fibroblasts, the cells built the niche through cell-shape change, vessel growth, and inflammation signals. Each link in the chain is a place where drugs might cut off liver spread.
Catalog record
| CREATOR | Jing Yu, Jiangning Xiang, Lin Yao, Shan Wang, Yifan Liu, Enli Chen, Xiaolin Liu, JinXiang Wu, Yuhao Wang, Lei Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |