A Molecular-Dynamics-Guided Screening Pipeline Identifies Topical Glucocorticoid Receptor Modulators with Selective Epidermal Activation
Feng-Chuan Tai, Heng-Hui Lien, Shih-Chang Lin, Yu-Li Hung, Yu-Ping Cheng, Jiun-Wen Guo · 2026
Read A Molecular-Dynamics-Guided Screening Pipeline Identifies Topical Glucocorticoid Receptor Modulators with Selective Epidermal Activation by Feng-Chuan Tai, Heng-Hui Lien, Shih-Chang Lin, Yu-Li Hung, Yu-Ping Cheng, Jiun-Wen Guo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13432936.txt.
Description
Feng-Chuan Tai and co-authors screened plant compounds in 2026 with computer models of motion, hunting for skin-safe triggers of a hormone port tied to psoriasis care. Skin steroids lead care for the scaly skin disease yet thin the skin and wear its wall down over time. Four plant picks went through dock tests, motion playbacks, and shape checks.
Two picks gripped the port hard and kept its key holds through the playbacks. Two more gripped at a fair level with steady form. Stains of kept skin samples showed the port stayed stocked for all picks. One pick lit the port's active mark the most, which hints at unlike signal tones by pick. Model reads and tissue reads pointed the same way at this early stage.
Catalog record
| CREATOR | Feng-Chuan Tai, Heng-Hui Lien, Shih-Chang Lin, Yu-Li Hung, Yu-Ping Cheng, Jiun-Wen Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70296 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |