Senescent Human Liver Endothelial Cells Mediate CD4 + T Cell Recruitment via ICOSL
Daniel A. Patten, Amy Lumley, Alex L. Wilkinson, Ayla O’Keeffe, Kelvin Yin, Niranjan Shirgaonkar, Ran Gao, Ramanuj DasGupta, Matthew Hoare, Shishir Shetty · 2026
Read Senescent Human Liver Endothelial Cells Mediate CD4 + T Cell Recruitment via ICOSL by Daniel A. Patten, Amy Lumley, Alex L. Wilkinson, Ayla O’Keeffe, Kelvin Yin, Niranjan Shirgaonkar, Ran Gao, Ramanuj DasGupta, Matthew Hoare, Shishir Shetty (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13431846.txt.
Description
Daniel A Patten and co-authors showed in 2026 that aged lining cells of the human liver can still draw immune cells in, and that one surface signal steers which cells arrive. Aged cells pile up in long-sick livers and feed harm, yet past study dwelt on the liver's main work cells and left its lining cells aside. The team hunted aged lining cells in sick human tissue with public gene data and tissue stains.
A new lab method let the group age healthy lining cells without harsh drugs. Aged cells lost some of their clean-up skill yet still pulled white cells across under flow that mimics blood. Blocking or cutting one signal, a partner tag for T cells, stopped the draw for helper T cells while killer T cells still came. Sick tissue showed more of that signal where helper cells pooled.
Catalog record
| CREATOR | Daniel A. Patten, Amy Lumley, Alex L. Wilkinson, Ayla O’Keeffe, Kelvin Yin, Niranjan Shirgaonkar, Ran Gao, Ramanuj DasGupta, Matthew Hoare, Shishir Shetty |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40469 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |