Intron retention in health and amyotrophic lateral sclerosis
Chloe Y Wang, Stephanie Taylor, Virenkumar A Pandya, Benjamin E Clarke, Koustav Pal, Tatyana A Shelkovnikova, Yiran Wang, Raphaëlle Luisier, Rickie Patani · 2026
Read Intron retention in health and amyotrophic lateral sclerosis by Chloe Y Wang, Stephanie Taylor, Virenkumar A Pandya, Benjamin E Clarke, Koustav Pal, Tatyana A Shelkovnikova, Yiran Wang, Raphaëlle Luisier, Rickie Patani (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13431790.txt.
Description
Wang and colleagues review intron retention, a quirk of gene reading in which the segments normally cut out of a gene's RNA copy stay in. Those leftover segments were once dismissed as junk, and retained copies were thought only to mute a gene's output. Their 2026 review gathers new work on retention in health and in amyotrophic lateral sclerosis, the fatal disease that paralyzes by killing motor neurons.
Retained copies behave differently by location: some stay in the nucleus and some reach the cell body, with distinct jobs in each place. They can steer where RNA protein complexes gather, drain the pool of working RNA binding proteins, and shift the droplet like clumping of cell material, all themes in ALS biology. Retention itself can act as a regulatory element beyond making protein. The authors flag retained introns as drug targets and expect machine learning to speed discovery.
Catalog record
| CREATOR | Chloe Y Wang, Stephanie Taylor, Virenkumar A Pandya, Benjamin E Clarke, Koustav Pal, Tatyana A Shelkovnikova, Yiran Wang, Raphaëlle Luisier, Rickie Patani |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |