Freeze-Killed M2 Macrophage-Encapsulated MXene Nanocomposites for Multifunctional Photothermal Therapy in Diabetic Wound Healing
Kaiyuan Chen, Hao Jiang, Yining Geng, Meichen Song, Yuxin Han, Sen Liu, Xingjiang Li, Xiaohuan Yuan, Jie Gao, Yan Wu · 2026
Read Freeze-Killed M2 Macrophage-Encapsulated MXene Nanocomposites for Multifunctional Photothermal Therapy in Diabetic Wound Healing by Kaiyuan Chen, Hao Jiang, Yining Geng, Meichen Song, Yuxin Han, Sen Liu, Xingjiang Li, Xiaohuan Yuan, Jie Gao, Yan Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13431467.txt.
Description
Chen and co-authors construct a wound dressing with a disguise in this 2026 study. The disguise is nanoparticles wrapped in the membranes of freeze-killed M2 macrophages. Macrophages are immune cells; the M2 type calms inflammation and promotes repair. The core particle is MXene, a two-dimensional material. It converts near-infrared light into heat. That gives the composite antibacterial photothermal power.
The coating kept the macrophages' structure and working proteins. It converted light to heat well. In lab tests it cut inflammatory cytokine release and neutralized harmful oxygen radicals. It killed both E. coli and Staphylococcus aureus bacteria. It also spurred new blood vessel growth. In diabetic mice with skin wounds, the material plus near-infrared light sped closure. It increased collagen deposition and nudged wound macrophages toward the healing M2 state. No obvious toxicity appeared at the tested dose.
Catalog record
| CREATOR | Kaiyuan Chen, Hao Jiang, Yining Geng, Meichen Song, Yuxin Han, Sen Liu, Xingjiang Li, Xiaohuan Yuan, Jie Gao, Yan Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |