The concise bioinspired total synthesis of the 4-hydroxy-2-pyridone family of natural products
Ricardo L. Cruz, Kyu-Hyun Sim, Benjamin N. Chiok, William M. Wuest · 2026
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Description
Ricardo L Cruz and co-authors laid out a short route in 2026 for building a whole family of fungus-fighting natural compounds in the lab. The family shares a ring core with an oxygen-rich pattern. Rather than craft each member from scratch, the team first made one shared core that carries two halogen handles at set spots.
From that core, step-by-step coupling rounds attach new parts at one handle at a time, with care for which spot reacts first. A final joining step, modeled on how nature may build these compounds, links a complex ring fragment with strong control over shape. Five natural members came out of the route, each in a modest chain of steps and with fair overall yield. The authors say the shared-core plan opens the family to deeper study of its effects on living cells.
Catalog record
| CREATOR | Ricardo L. Cruz, Kyu-Hyun Sim, Benjamin N. Chiok, William M. Wuest |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |