Predicting Anastomotic Leak After Neoadjuvant Chemoimmunotherapy and Esophagectomy: A Dynamic Inflammatory and Nutritional Biomarker Model
Zhenyuan Yang, Yizhou Huang, Maohui Chen, Bingqiang Cai, Hongmu Li, Taidui Zeng, Shuliang Zhang, Chun Chen, Bin Zheng · 2026
Read Predicting Anastomotic Leak After Neoadjuvant Chemoimmunotherapy and Esophagectomy: A Dynamic Inflammatory and Nutritional Biomarker Model by Zhenyuan Yang, Yizhou Huang, Maohui Chen, Bingqiang Cai, Hongmu Li, Taidui Zeng, Shuliang Zhang, Chun Chen, Bin Zheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13431432.txt.
Description
Yang and colleagues built a prediction model in 2026 for anastomotic leak after esophagus removal. A leak is a dangerous failure of the surgical join, and the patients studied had first received combined chemotherapy and immunotherapy. The study covered locally advanced esophageal squamous cell cancer at two centers.
Among 550 patients, leaks occurred in about one in ten in both the 350-person training group and the 200-person validation group, and most leaks were at the neck join. The final model combined changes in three blood indexes of inflammation and nutrition with low body mass index and poorer daily functioning. It separated patients who leaked from those who did not with good accuracy in training and acceptable accuracy in outside validation.
Catalog record
| CREATOR | Zhenyuan Yang, Yizhou Huang, Maohui Chen, Bingqiang Cai, Hongmu Li, Taidui Zeng, Shuliang Zhang, Chun Chen, Bin Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |