Hemophagocytic Lymphohistiocytosis Triggered by HSV‑1 in a Patient with Refractory Crohn’s Disease After Long‑Term Sequential Immunosuppressive Therapy
Lingya Yao, Hanxiao Tu, Qian Cao · 2026
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Description
Yao, Tu, and Cao present a cautionary case in this 2026 report. A young man with psoriasis and refractory Crohn's disease developed hemophagocytic lymphohistiocytosis. In that rare syndrome the immune system spirals into destructive overactivation. His bowel disease had resisted multiple therapies before he started the immune-suppressing drug upadacitinib in 2023.
Even on treatment, his colonoscopies showed suboptimal control, and in November 2024 he arrived at hospital with fever and elevated liver enzymes. Testing revealed herpes simplex virus type 1 as the trigger for the immune storm, on top of years of accumulated immunosuppression. Antiviral drugs and hormone therapy stabilized him, and he was discharged in stable condition. The authors stress that no single drug caused the crisis; the convergence of active Crohn's disease, layered immune suppression, and an acute viral infection did.
Catalog record
| CREATOR | Lingya Yao, Hanxiao Tu, Qian Cao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |