Clinical Phenotypes Associated with NRXN1 Deletions in Five Children with Autism Spectrum Disorder in Oman
Samira Said AlHousni, Ahmed Idris, Watfa Al-Mamari, Abeer Al-Sayegh · 2026
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Description
AlHousni and colleagues described in 2026 five children in Oman with autism and deletions in a gene called NRXN1. This gene helps synapses, the junctions where nerve cells pass signals, work properly. The children were seen at a genetics clinic in Muscat between 2011 and 2023. Each carried a small deletion, a missing stretch of DNA, in NRXN1 and met standard criteria for autism spectrum disorder.
All five children had speech and language delays together with cognitive impairment, meaning reduced learning ability. Four had a smaller than usual head size, and three families reported parents who were blood relatives. One child had generalised seizures and one had attention deficit hyperactivity disorder alongside autism. The authors stress how varied the picture can be even with the same gene change.
Catalog record
| CREATOR | Samira Said AlHousni, Ahmed Idris, Watfa Al-Mamari, Abeer Al-Sayegh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |