Exosomal delivery of METTL3 promotes M1 macrophage polarization by inducing miR-155-5p maturation via m6A modification
Xinyu Wu, Hongbo Gong, Jie Zhang, Ling Yu, Xiangyu Yan, Wanlong Pan, Chaoyue Liu · 2026
Read Exosomal delivery of METTL3 promotes M1 macrophage polarization by inducing miR-155-5p maturation via m6A modification by Xinyu Wu, Hongbo Gong, Jie Zhang, Ling Yu, Xiangyu Yan, Wanlong Pan, Chaoyue Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13431022.txt.
Description
Xinyu Wu and colleagues show how tiny cell parcels called exosomes can push macrophages, immune eating cells, toward their inflammatory M1 state. The parcels carry an enzyme, METTL3, that tags RNA messages with a chemical mark called m6A, which can change how the message is used.
Macrophages loaded with extra METTL3 showed higher m6A levels and turned on M1 markers and inflammatory signals. Blocking METTL3 flipped the pattern, calming the same markers and signals. The enzyme worked by maturing a small RNA, miR-155-5p, which then drove the inflammatory switch and its alarm pathways. Mouse tests matched the dish results, so Wu names this chain as a target for inflammation and tumour therapy.
Catalog record
| CREATOR | Xinyu Wu, Hongbo Gong, Jie Zhang, Ling Yu, Xiangyu Yan, Wanlong Pan, Chaoyue Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |