Chronic Smoking Impairs Glymphatic Transport and Cognitive Function in Adolescent Mice Through Cardiac, Vascular, and Perivascular Aquaporin‐4 Mechanisms
Chuanxiang Lv, Chengyu Xia, Zean Li, Tao Liu, Zhuang Sha, Shiying Dong, Yu Qian, Mingqi Liu, Kang Zhang, Xinran Zhang, Rongcai Jiang, Li Bie · 2026
Read Chronic Smoking Impairs Glymphatic Transport and Cognitive Function in Adolescent Mice Through Cardiac, Vascular, and Perivascular Aquaporin‐4 Mechanisms by Chuanxiang Lv, Chengyu Xia, Zean Li, Tao Liu, Zhuang Sha, Shiying Dong, Yu Qian, Mingqi Liu, Kang Zhang, Xinran Zhang, Rongcai Jiang, Li Bie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13430975.txt.
Description
Lv and colleagues trace how chronic smoking harms the adolescent brain in this 2026 mouse study. Smoking is a major dementia risk factor, especially when started young, and the brain's glymphatic system, a waste-clearance network, is suspected to be involved. The team exposed adolescent mice to chronic smoke and measured glymphatic transport with microscopy, alongside heart function, tau protein buildup, and performance in maze and object-recognition tests.
The longer the exposure, the worse glymphatic transport became, and phosphorylated tau accumulated in the hippocampus's dentate gyrus while new synapses and new neurons there dwindled. Cognition declined in step with these changes across the exposure period. The authors link the clearance failure to three cooperating problems. The heart ejected more weakly. Arterial pulsatility, the pulse that drives fluid flow, was reduced. And the aquaporin-4 water channel around blood vessels was lost.
Catalog record
| CREATOR | Chuanxiang Lv, Chengyu Xia, Zean Li, Tao Liu, Zhuang Sha, Shiying Dong, Yu Qian, Mingqi Liu, Kang Zhang, Xinran Zhang, Rongcai Jiang, Li Bie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |