Repeated head impacts establish a senescent cranial bone marrow niche that impairs brain metabolism
Patrick J Devlin, Romeesa Khan, Trang H Do, Bryce E West, Janelle M Korf, Gary U Guzman, John Ahn, Alexander Saltzman, Antrix Jain, Chunfeng Tan, Rene Flores, Micheal E Maniskas, Sean P Marrelli, Anna Malovannaya, Erica Underwood, Rodney M Ritzel · 2026
Read Repeated head impacts establish a senescent cranial bone marrow niche that impairs brain metabolism by Patrick J Devlin, Romeesa Khan, Trang H Do, Bryce E West, Janelle M Korf, Gary U Guzman, John Ahn, Alexander Saltzman, Antrix Jain, Chunfeng Tan, Rene Flores, Micheal E Maniskas, Sean P Marrelli, Anna Malovannaya, Erica Underwood, Rodney M Ritzel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13430884.txt.
Description
Patrick J Devlin and colleagues ask how repeated head impacts age the skull's bone marrow and harm brain metabolism. Brain injury of any severity links to lasting body-wide inflammation and later illness, yet immune disruption after repeated sub-concussive hits stayed poorly mapped.
Mice received a modified weight-drop model with twisting and acceleration forces, three hits a week for up to sixteen weeks, with no deaths, skull breaks, bleeding, or brain immune-cell invasion. Marrow stem and progenitor growth, ageing, and output were tracked in leg and skull marrow by flow tests, ageing assays, telomere study, and secreted-protein profiling. The work probes a skull-marrow route from repeated hits to brain decline.
Catalog record
| CREATOR | Patrick J Devlin, Romeesa Khan, Trang H Do, Bryce E West, Janelle M Korf, Gary U Guzman, John Ahn, Alexander Saltzman, Antrix Jain, Chunfeng Tan, Rene Flores, Micheal E Maniskas, Sean P Marrelli, Anna Malovannaya, Erica Underwood, Rodney M Ritzel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |