Hepatic fibro-inflammation measured by magnetic resonance imaging iron-corrected T1 predicts extrahepatic cancer risk: a UK Biobank study
Hye Yeon Chon, Seok-Jae Heo, SungA Bae, Tae Seop Lim, Ja Kyung Kim · 2026
Read Hepatic fibro-inflammation measured by magnetic resonance imaging iron-corrected T1 predicts extrahepatic cancer risk: a UK Biobank study by Hye Yeon Chon, Seok-Jae Heo, SungA Bae, Tae Seop Lim, Ja Kyung Kim (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13430323.txt.
Description
Chon and colleagues tested whether a liver MRI measure called iron-corrected T1, which reflects liver inflammation and scarring combined, also predicts cancers outside the liver in the general population. They followed 24,003 cancer-free UK Biobank participants with liver imaging and complete data over a median of 4.28 years during the study.
During follow-up, 1,144 participants developed an extrahepatic malignancy, meaning a cancer arising outside the liver itself. Each standard deviation rise in the MRI measure carried a hazard ratio of 1.116 for future cancer after adjustment for demographic, metabolic, and liver factors. People above the 771 millisecond cutoff showed a cumulative incidence of 6.1 percent, versus 4.6 percent below it in the cohort. Older age and male sex also predicted risk, while liver fat fraction pointed the opposite way, leading the authors to suggest the marker captures systemic processes.
Catalog record
| CREATOR | Hye Yeon Chon, Seok-Jae Heo, SungA Bae, Tae Seop Lim, Ja Kyung Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |