Global genomic landscape of the Klebsiella oxytoca complex: diversity, resistome and plasmidome (1974-2025)
Wentao Zhu, Xi Chen, Hong Shen, Chunxia Yang, Qian Liu, Li Gu · 2026
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Description
Wentao Zhu and colleagues assemble, in a 2026 study, the largest genomic portrait yet of a bacterial complex that quietly carries drug resistance. The Klebsiella oxytoca complex lives in the human gut yet can turn opportunist and cause infections. The team gathered 3,097 quality-checked genomes collected worldwide between 1974 and 2025. Family analysis sorted them into six species, dominated by two members that together supplied about 85 percent.
Four hundred sixty strain types showed how diverse the complex is. Genomes carried a median of five resistance genes each, with one species carrying the most. Forty-four kinds of carbapenemase genes, which defeat last-resort antibiotics, appeared across 37 countries. Certain mobile DNA elements traveled with resistance genes often enough to implicate them in spread. Surveillance programs gain priority targets inside a complex hospitals rarely distinguish.
Catalog record
| CREATOR | Wentao Zhu, Xi Chen, Hong Shen, Chunxia Yang, Qian Liu, Li Gu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |