Exogenous adiponectin attenuates lipid accumulation and is associated with enhanced TG and VLDL secretion in primary chicken hepatocytes
Dan Wang, Qingmei Hu, Kelin Li, Qing Jia, Hai Lin, Jingpeng Zhao, Hongchao Jiao, Xiaojuan Wang · 2026
Read Exogenous adiponectin attenuates lipid accumulation and is associated with enhanced TG and VLDL secretion in primary chicken hepatocytes by Dan Wang, Qingmei Hu, Kelin Li, Qing Jia, Hai Lin, Jingpeng Zhao, Hongchao Jiao, Xiaojuan Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13430181.txt.
Description
Dan Wang and co-authors examine, in a 2026 study, how a fat-cell hormone changes lipid handling in chicken liver cells. Adiponectin guides fat metabolism in mammals, yet its role in birds, whose livers do most fat making, was unclear. The team treated primary chicken liver cells with lab-made adiponectin, with and without a fatty acid preload that mimics overload. Cell fat content, exported fats, and gene activity were all measured.
Adiponectin cut the fat stored inside cells under both conditions. It raised the receptor that receives its own signal and pushed more triglycerides and fat-carrying particles out of the cells. A key energy-sensing pathway switched on briefly. Curiously, cells also took up more sugar and fat while quieting their fat-burning genes, a feedback pattern the authors note. Export, they conclude, is the main drain the hormone opens.
Catalog record
| CREATOR | Dan Wang, Qingmei Hu, Kelin Li, Qing Jia, Hai Lin, Jingpeng Zhao, Hongchao Jiao, Xiaojuan Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58409 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |