Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation–driven model
Reuben Kapur, Linke Li, Rahul Kanumuri, Kanaka Sai Ram Padam, Baskar Ramdas, Chiranjeevi Pasala, Gabriela Chiosis, Lakshmi Reddy Palam, Ramesh Kumar, Satoshi Koyama, Pradeep Natarajan, Laura S. Haneline, Zhi Yu, Santhosh Kumar Pasupuleti · 2026
Read Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation–driven model by Reuben Kapur, Linke Li, Rahul Kanumuri, Kanaka Sai Ram Padam, Baskar Ramdas, Chiranjeevi Pasala, Gabriela Chiosis, Lakshmi Reddy Palam, Ramesh Kumar, Satoshi Koyama, Pradeep Natarajan, Laura S. Haneline, Zhi Yu, Santhosh Kumar Pasupuleti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13430024.txt.
Description
Reuben Kapur and co-authors show, in a 2026 study, that obesity can feed a mutation-driven blood cancer, and that two existing drug types can starve it back. Data from over 440,000 UK Biobank participants linked obesity traits with higher levels of an inflammatory signal, IL-17A, and greater myeloid cancer risk. Mutant blood stem cells carrying a fault in the PTPN11 gene were transplanted into lean and obese mice to test the connection directly.
In obese mice the mutant cells expanded faster, rewired fat metabolism, and surrounded themselves with suppressive macrophages while T cells tired. A drug pair, an antibody blocking IL-17A plus a GLP-1 drug of the type used for diabetes and weight loss, reversed much of that picture. Immune presentation recovered, T cells reawakened, and leukemia burden fell. Metabolic treatment as cancer support is the provocative suggestion.
Catalog record
| CREATOR | Reuben Kapur, Linke Li, Rahul Kanumuri, Kanaka Sai Ram Padam, Baskar Ramdas, Chiranjeevi Pasala, Gabriela Chiosis, Lakshmi Reddy Palam, Ramesh Kumar, Satoshi Koyama, Pradeep Natarajan, Laura S. Haneline, Zhi Yu, Santhosh Kumar Pasupuleti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55794 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |