CPT1A, CYGB, and MRPL3 in pre-eclampsia: biomarkers identified from oxidative stress-related gene analysis
Ling Chen, Meiting Wu · 2026
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Description
Chen and Wu searched in 2026 for gene markers of pre-eclampsia, the dangerous rise in blood pressure during pregnancy. They focused on genes tied to oxidative stress, the damage caused by excess reactive oxygen in tissues. They mined a public gene expression dataset.
Network analysis first narrowed the field to 359 shared genes, and three machine learning methods then picked out CPT1A, CYGB, and MRPL3 as the strongest candidates. A diagnostic model built on the three genes separated patients from controls with high accuracy. Its discrimination score stayed well above nine tenths through the validation checks in the dataset. The genes also tracked with immune cell patterns in the tissue. In cell experiments, silencing CPT1A reduced reactive oxygen levels and cell death in placenta-like cells stressed by low then restored oxygen.
Catalog record
| CREATOR | Ling Chen, Meiting Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |