Immune checkpoint LAG-3 governs stage-dependent and disease-associated microglial modules in ALS model mice
Yuta Morisaki, Nanaka Nomura, Motoki Ohshima, Miruto Matsuda, Okiru Komine, Takashi Okuda, Koji Yamanaka, Hidemi Misawa · 2026
Read Immune checkpoint LAG-3 governs stage-dependent and disease-associated microglial modules in ALS model mice by Yuta Morisaki, Nanaka Nomura, Motoki Ohshima, Miruto Matsuda, Okiru Komine, Takashi Okuda, Koji Yamanaka, Hidemi Misawa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13428418.txt.
Description
Yuta Morisaki and co-authors study, in a 2026 mouse study, an immune brake protein on the brain's resident immune cells in ALS. Amyotrophic lateral sclerosis kills motor neurons, and inflammation driven by microglia, the brain's own immune cells, shapes how fast it moves. The protein LAG-3 normally restrains T cells, yet its role in microglia was unexplored. In mice carrying a human ALS gene fault, LAG-3 rose on spinal cord microglia as disease advanced.
Removing LAG-3 gave a two-sided result: disease started sooner, yet its later course stretched longer. Early on, microglia without the brake reacted more fiercely. Later they quieted inflammatory signals while keeping their cleanup functions, and lab tests showed stronger engulfing of debris. Spinal cord tissue health improved in parallel. Timing, the authors argue, decides whether loosening this brake helps or harms.
Catalog record
| CREATOR | Yuta Morisaki, Nanaka Nomura, Motoki Ohshima, Miruto Matsuda, Okiru Komine, Takashi Okuda, Koji Yamanaka, Hidemi Misawa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64800 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |