Early‐Onset Gastric Cancer as a High‐Risk Disease Entity in the United States: Clinicopathologic Features, Regional Variation, and Outcomes
Dani R. Castillo, Pranati Shah, Derek Tai, Mengni Guo, Max Hazeltine, Sofia Guzman, Daniel Park, Rifat Mannan, Yan Xing, Gagandeep Brar, Mustafa Raoof, Cathy Eng, Shengyang Wu · 2026
Read Early‐Onset Gastric Cancer as a High‐Risk Disease Entity in the United States: Clinicopathologic Features, Regional Variation, and Outcomes by Dani R. Castillo, Pranati Shah, Derek Tai, Mengni Guo, Max Hazeltine, Sofia Guzman, Daniel Park, Rifat Mannan, Yan Xing, Gagandeep Brar, Mustafa Raoof, Cathy Eng, Shengyang Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13428078.txt.
Description
Castillo and colleagues chart early onset gastric cancer, stomach cancer diagnosed by age 45, in the United States National Cancer Database. The team studies patients with stage two or three disease who had curative stomach surgery between 2006 and 2022. It compares the young group with older patients on traits, treatment, and survival. Young cases made up a small slice of the cohort.
Early onset cases clustered among Hispanic, Black, and Asian patients. Their tumors more often showed diffuse or signet ring cell patterns, poor differentiation, meaning cells looked abnormal, and heavier lymph node spread. Young patients received drug treatment around surgery more often than older patients, yet full tumor disappearance under those drugs stayed rare. Survival did not beat the older groups despite the stronger therapy. The authors call the young disease a high risk entity that needs targeted treatments and earlier detection in the groups hit most.
Catalog record
| CREATOR | Dani R. Castillo, Pranati Shah, Derek Tai, Mengni Guo, Max Hazeltine, Sofia Guzman, Daniel Park, Rifat Mannan, Yan Xing, Gagandeep Brar, Mustafa Raoof, Cathy Eng, Shengyang Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |