Potent and Sustained Lowering of Serum Uric Acid by YJH‐012‐D, a GalNAc‐Conjugated siRNA Targeting Xanthine Dehydrogenase
Tingke Tang, Qiuying Li, Chenguang Zhang, Yongxing Wang, Lu Yang, Haibin Huang, Yujun He, Zhi Zheng, Dong Liang, Meng Wang, Yingyu Wu, Chengjiang Zhao, Wenhao Cui · 2026
Read Potent and Sustained Lowering of Serum Uric Acid by YJH‐012‐D, a GalNAc‐Conjugated siRNA Targeting Xanthine Dehydrogenase by Tingke Tang, Qiuying Li, Chenguang Zhang, Yongxing Wang, Lu Yang, Haibin Huang, Yujun He, Zhi Zheng, Dong Liang, Meng Wang, Yingyu Wu, Chengjiang Zhao, Wenhao Cui (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13428038.txt.
Description
Tang and colleagues develop a gene silencing injection that lowers uric acid for months after one dose. High uric acid, the driver of gout, comes largely from the liver enzyme xanthine dehydrogenase. Their 2026 preclinical study builds a small interfering RNA, a molecule that switches off one chosen gene. A sugar tag steers it into liver cells. It is tested in human liver cells, mice, and cynomolgus monkeys.
The RNA strongly cut the enzyme's message and protein in liver cells. One under skin dose in mice lowered blood uric acid and liver enzyme levels for more than six weeks. In monkeys, one dose held uric acid down for up to half a year, with enzyme suppression lasting about four months. The drug piled up in liver, thousands fold over blood, and lingered for weeks. Full safety checks, including off target gene scans, found no harm.
Catalog record
| CREATOR | Tingke Tang, Qiuying Li, Chenguang Zhang, Yongxing Wang, Lu Yang, Haibin Huang, Yujun He, Zhi Zheng, Dong Liang, Meng Wang, Yingyu Wu, Chengjiang Zhao, Wenhao Cui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |