Assessing radiological response of IDH-mutated glioma to vorasidenib by tumor diameter slopes: a series of 8 cases
Emmanuel Mandonnet · 2026
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Description
Emmanuel Mandonnet studies eight people with IDH-mutated low-grade glioma in the INDIGO trial, asking how each tumour's size changed on vorasidenib. The trial had already shown longer time without progression on the drug, but the shape of response per person stayed unknown.
Tumour diameters from FLAIR volume scans were tracked before and during treatment, with slopes fitted for each patient. Three showed no slope change, three showed a marked slope fall, and two showed a slope flip. The series argues that single-patient slopes reveal responses that group averages hide, a useful lens for slow brain tumours.
Catalog record
| CREATOR | Emmanuel Mandonnet |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |