Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis
Alessandra I. Riggio, Kerri Sweeney, Robin Shaw, Amy Lawlor, Adiba Khan, Nicola Ferrari, Jayanthi Anand, Laura CA Galbraith, Kathryn Gilroy, Courtney Bull, Alex L. Young, Dimitris Athineos, Holly Hall, Farah Ghaffar, Mark Hughes, Claire A. Mitchell, Louise Mitchell, Colin Nixon, Peter D. Adams, Edwa · 2026
Read Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis by Alessandra I. Riggio, Kerri Sweeney, Robin Shaw, Amy Lawlor, Adiba Khan, Nicola Ferrari, Jayanthi Anand, Laura CA Galbraith, Kathryn Gilroy, Courtney Bull, Alex L. Young, Dimitris Athineos, Holly Hall, Farah Ghaffar, Mark Hughes, Claire A. Mitchell, Louise Mitchell, Colin Nixon, Peter D. Adams, Edwa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13427844.txt.
Description
Alessandra I Riggio, Kerri Sweeney, and a large team of co-authors show that two related genes team up to hold back breast cancer. Their 2026 study examines Runx1 and Runx2, whose family is often mutated in breast tumors, though their protective role was unproven. Mouse models of breast cancer carried the test.
Losing Runx1 alone sped tumor onset and growth. Losing both genes made mammary cells strikingly sensitive to transformation driven by the Wnt signal path, with many tumors emerging fast. Runx1 loss also pushed cells toward a stem like state. Gene activity scans showed the Wnt path switching on. Stem cell assays, tissue stains, and RNA reads fill out the picture. The pair act as joint brakes on a known cancer driver.
Catalog record
| CREATOR | Alessandra I. Riggio, Kerri Sweeney, Robin Shaw, Amy Lawlor, Adiba Khan, Nicola Ferrari, Jayanthi Anand, Laura CA Galbraith, Kathryn Gilroy, Courtney Bull, Alex L. Young, Dimitris Athineos, Holly Hall, Farah Ghaffar, Mark Hughes, Claire A. Mitchell, Louise Mitchell, Colin Nixon, Peter D. Adams, Edwa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |