Structures of EHD2 filaments on curved membranes provide a model for caveolar neck stabilization
Elena Vázquez-Sarandeses, Vasilii Mikirtumov, Jeffrey K. Noel, Mikhail Kudryashev, Oliver Daumke · 2026
Read Structures of EHD2 filaments on curved membranes provide a model for caveolar neck stabilization by Elena Vázquez-Sarandeses, Vasilii Mikirtumov, Jeffrey K. Noel, Mikhail Kudryashev, Oliver Daumke (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13427840.txt.
Description
Vázquez-Sarandeses and colleagues published a 2026 study on the tiny flasks that dot cell surfaces. Caveolae are flask-shaped dents that guard cells against stretch and strain. A protein called EHD2 is thought to ring the neck of each flask. The team imaged EHD2 threads on curved membranes at fine detail.
The images show EHD2 forming rings that cradle wavy, tube-like membrane shapes. A short protein tail acts as a spacer between neighboring rings. Those waves match the shape of real caveola necks in cells. In cells lacking EHD2, caveola necks grew narrower and longer than normal. The structure gives a working model for how necks stay stable. Such scaffolds may also shield the flasks from squeezing forces in tissue.
Catalog record
| CREATOR | Elena Vázquez-Sarandeses, Vasilii Mikirtumov, Jeffrey K. Noel, Mikhail Kudryashev, Oliver Daumke |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |