Circulating tumour cell-derived xenograft as a preclinical platform for metastatic breast cancer
Zuzana Kahounová, Markéta Hrušková, Stanislav Drápela, Ondřej Naar, Ráchel Víchová, Jiří Navrátil, Pavel Fabian, Filip Zavadil Kokáš, Aleš Hampl, Jan Bouchal, Karel Souček · 2026
Read Circulating tumour cell-derived xenograft as a preclinical platform for metastatic breast cancer by Zuzana Kahounová, Markéta Hrušková, Stanislav Drápela, Ondřej Naar, Ráchel Víchová, Jiří Navrátil, Pavel Fabian, Filip Zavadil Kokáš, Aleš Hampl, Jan Bouchal, Karel Souček (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13427727.txt.
Description
Zuzana Kahounová, Markéta Hrušková, and Stanislav Drápela lead a team growing a patient's own circulating tumor cells into a mouse model of metastatic breast cancer. Their paper appeared in two thousand twenty-six. Cells shed into the blood seed the metastases that kill most patients. Models grown from those very cells are rare and prized.
Blood from a patient with advanced ductal cancer yielded a cell fraction that formed a tumor in mice within months. The graft's spreading power was confirmed in further assays. Grown in dishes, the cells were rich in stem-like markers. Gene readouts showed deep changes from the original tumor in growth and signaling. Drug tests found sensitivity to a standard chemotherapy agent. A second drug, picked by computer analysis, partly worked too. The model opens a window on how circulating cells behave.
Catalog record
| CREATOR | Zuzana Kahounová, Markéta Hrušková, Stanislav Drápela, Ondřej Naar, Ráchel Víchová, Jiří Navrátil, Pavel Fabian, Filip Zavadil Kokáš, Aleš Hampl, Jan Bouchal, Karel Souček |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |