Early-Stage Oral Squamous Cell Carcinoma in Adolescents and Young Adults Compared with Older Patients Exhibits Distinct Clinicopathological Features
Sawako Ono, Katsutoshi Hirose, Hotaka Kawai, Tatsuya Abe, Shintaro Sukegawa, Masanori Masui, Chihoko Ikeda, Madoka Isomura, Yuri Tachibana, Junya Ono, Katsumitsu Shimada, Hitoshi Nagatsuka, Hidetaka Yamamoto · 2026
Read Early-Stage Oral Squamous Cell Carcinoma in Adolescents and Young Adults Compared with Older Patients Exhibits Distinct Clinicopathological Features by Sawako Ono, Katsutoshi Hirose, Hotaka Kawai, Tatsuya Abe, Shintaro Sukegawa, Masanori Masui, Chihoko Ikeda, Madoka Isomura, Yuri Tachibana, Junya Ono, Katsumitsu Shimada, Hitoshi Nagatsuka, Hidetaka Yamamoto (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13427714.txt.
Description
Ono and colleagues reported in 2026 on early-stage mouth cancer, oral squamous cell carcinoma, in patients aged 15 to 39 years. Cancers in this young group may behave in distinct ways from those in older people. The team compared 48 young patients with 69 patients aged 65 or older, all treated with surgery for stage I or II disease, and tested tumor tissue with stains and gene probes.
Ono found that young patients' tumors sat on the tongue far more often, in nearly all cases, and spread along the surface more often. Their tumors also showed more budding, small clusters of cancer cells at the edge, and more abnormal p53 stain patterns. Even so, young patients survived better overall. Invasion deeper than 5 millimetres was the strongest warning sign in the young group.
Catalog record
| CREATOR | Sawako Ono, Katsutoshi Hirose, Hotaka Kawai, Tatsuya Abe, Shintaro Sukegawa, Masanori Masui, Chihoko Ikeda, Madoka Isomura, Yuri Tachibana, Junya Ono, Katsumitsu Shimada, Hitoshi Nagatsuka, Hidetaka Yamamoto |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |