Dual roles of SBSN in renal cancer progression and tumor thrombus: Cell-autonomous NF-κB-CD44 axis and IFI6-driven paracrine angiogenesis
Yuedian Ye, Jinbin Xu, Weihao Liu, Zhansen Huang, Xiaoming Li, Jiang Li, Yuanpeng Liao, Sam Un Cheong, Zifeng Xu, Gengguo Deng, Tiantian Wang, Jinming Di · 2026
Read Dual roles of SBSN in renal cancer progression and tumor thrombus: Cell-autonomous NF-κB-CD44 axis and IFI6-driven paracrine angiogenesis by Yuedian Ye, Jinbin Xu, Weihao Liu, Zhansen Huang, Xiaoming Li, Jiang Li, Yuanpeng Liao, Sam Un Cheong, Zifeng Xu, Gengguo Deng, Tiantian Wang, Jinming Di (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13427577.txt.
Description
Yuedian Ye and co-authors report, in 2026, two ways one protein helps kidney cancer grow and spread into veins. The protein, called suprabasin or SBSN, was higher in tumor tissue than in healthy kidney. High levels also marked tumors that had grown a clot-like extension into a vein, a pattern tied to worse outlook. Lab tests tied SBSN to faster cell growth and movement.
Inside cancer cells, SBSN switched on a signal chain ending in CD44, a surface protein linked to spread. It also raised a second protein in nearby vessel cells, which kept those cells alive and helped them form tubes. Blocking either route could starve tumors of blood while slowing the cells themselves. The authors propose SBSN as both a warning marker and a drug target.
Catalog record
| CREATOR | Yuedian Ye, Jinbin Xu, Weihao Liu, Zhansen Huang, Xiaoming Li, Jiang Li, Yuanpeng Liao, Sam Un Cheong, Zifeng Xu, Gengguo Deng, Tiantian Wang, Jinming Di |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58580 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |