Safety and feasibility of oral zinc for patients with GNAO1-related disorders (ZINCGNAO1): an open-label, single-arm, single-centre, pilot trial in Germany
Moritz Thiel, Kyriakos Martakis, Ibrahim Duran, Hormos S Dafsari, Petra Schiller, Jithmi Weliwitage, Barbara Hero, Yonika Larasati, Alexey Koval, Vladimir L Katanaev, Anne Koy · 2026
Read Safety and feasibility of oral zinc for patients with GNAO1-related disorders (ZINCGNAO1): an open-label, single-arm, single-centre, pilot trial in Germany by Moritz Thiel, Kyriakos Martakis, Ibrahim Duran, Hormos S Dafsari, Petra Schiller, Jithmi Weliwitage, Barbara Hero, Yonika Larasati, Alexey Koval, Vladimir L Katanaev, Anne Koy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13427569.txt.
Description
Moritz Thiel and co-authors report, in 2026, a small German trial of zinc tablets for children and young adults with GNAO1-related disorders. Faults in the GNAO1 gene cause movement problems, epilepsy, and delays in learning and growth. No treatment now fixes the faulty protein, though lab work shows zinc can partly restore its function. Thirteen patients aged from infancy to 25 took part for six months.
Zinc was given by mouth in doses set by age, and the main questions were safety and whether families could stick with it. Eleven of the 13 finished, and families managed the dosing on most days. Movement, motor skills, and quality of life were tracked as early signals only. A pilot this small guides design of a larger trial rather than proving zinc helps.
Catalog record
| CREATOR | Moritz Thiel, Kyriakos Martakis, Ibrahim Duran, Hormos S Dafsari, Petra Schiller, Jithmi Weliwitage, Barbara Hero, Yonika Larasati, Alexey Koval, Vladimir L Katanaev, Anne Koy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59694 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |