Higher Expression of miR-155 and miR-103 in Patients with Gitelman Syndrome: Potential Implications for Angiotensin II-Induced Cardiovascular Remodeling in Hypertension
Martina Cacciapuoti, Ilaria Caputo, Giulia Driussi, Paul A. Davis, Federico Nalesso, Lorenzo A. Calò · 2026
Read Higher Expression of miR-155 and miR-103 in Patients with Gitelman Syndrome: Potential Implications for Angiotensin II-Induced Cardiovascular Remodeling in Hypertension by Martina Cacciapuoti, Ilaria Caputo, Giulia Driussi, Paul A. Davis, Federico Nalesso, Lorenzo A. Calò (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13427314.txt.
Description
Martina Cacciapuoti and coauthors measured two microRNAs in Gitelman syndrome in a 2026 study using the rare salt-wasting tubulopathy as a natural model. People with Gitelman syndrome are protected from angiotensin II driven cardiovascular remodeling, so their biology mimics lifelong blockade of that hormone pathway. Sixteen patients from the Padua nephrology cohort were compared with twenty-one matched healthy volunteers for plasma miR-155 and miR-103, both implicated in angiotensin signaling and hypertension.
Expression of both microRNAs was higher in patients in the study's framing, complicating simple stories about their role in vessel remodeling. Clarifying these signals could refine understanding of how angiotensin reshapes the cardiovascular system. The Padua group has long kept a roll of such rare cases, which lets a test like this draw on years of stored blood and case notes.
Catalog record
| CREATOR | Martina Cacciapuoti, Ilaria Caputo, Giulia Driussi, Paul A. Davis, Federico Nalesso, Lorenzo A. Calò |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22988 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |