Feiwei Heji Enhances Antitumor Immunity by MLL4‐Dependent Regulation of Pyroptosis in Lung Cancer
Nan Cheng, Ruoyu Jiang, Wei Li, Wenjie Huang, Qiao Peng, Tong Zhao, Chufeng Zhang · 2026
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Description
Nan Cheng and colleagues tested Feiwei Heji, a traditional Chinese herbal formula, against lung cancer in tumour-bearing mice. The formula is used for lung cancer patients marked by low energy and dryness in traditional practice terms.
Chemical tests found four main active parts, including naringin and chlorogenic acid. Fed by mouth, the formula slowed tumour growth and switched on pyroptosis, a fiery form of cell death that alerts the immune system. It also raised the share of killer T cells inside tumours and boosted their activity signals. The effect ran through a gene regulator called MLL4, since forcing MLL4 back up largely cancelled the benefit.
Catalog record
| CREATOR | Nan Cheng, Ruoyu Jiang, Wei Li, Wenjie Huang, Qiao Peng, Tong Zhao, Chufeng Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |