Population bottlenecks and temporal constraints shape dengue virus infection of Aedes aegypti midguts
Godfrey Nattoh, Philip M. Armstrong, Doug E. Brackney, Abdallah Samy, Ran Wang, Abdallah Samy, Ran Wang, Abdallah Samy, Ran Wang · 2026
Read Population bottlenecks and temporal constraints shape dengue virus infection of Aedes aegypti midguts by Godfrey Nattoh, Philip M. Armstrong, Doug E. Brackney, Abdallah Samy, Ran Wang, Abdallah Samy, Ran Wang, Abdallah Samy, Ran Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13426913.txt.
Description
Godfrey Nattoh and colleagues watched the first hours of dengue virus infection inside mosquito guts, using a new signal-boosting detection method. Dengue spreads to people through Aedes aegypti mosquitoes, and the gut is the first barrier the virus must cross.
The new method proved far more sensitive than the standard antibody test and spotted virus as early as six hours after infection. Only a handful of virus particles started each gut infection, showing a severe early bottleneck for the virus. That narrow start can reshape the virus population and its fitness for later spread. Nattoh argues these early events are a promising target for new ways to block transmission.
Catalog record
| CREATOR | Godfrey Nattoh, Philip M. Armstrong, Doug E. Brackney, Abdallah Samy, Ran Wang, Abdallah Samy, Ran Wang, Abdallah Samy, Ran Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |