Timing of 17-hydroxyprogesterone measurement during the standard-dose Synacthen test in pediatric patients evaluated for non-classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Nurdan Çiftci, Emine Çamtosun, İsmail Dündar, Edip Ünal, Nurullah Çelik, Ayşehan Akıncı · 2026
Read Timing of 17-hydroxyprogesterone measurement during the standard-dose Synacthen test in pediatric patients evaluated for non-classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency by Nurdan Çiftci, Emine Çamtosun, İsmail Dündar, Edip Ünal, Nurullah Çelik, Ayşehan Akıncı (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13426900.txt.
Description
Çiftci and colleagues reported in 2026 on the best timing for a hormone test in children. The test checks for a mild form of congenital adrenal hyperplasia, a gland disorder caused by low levels of one enzyme. Doctors use the Synacthen test, which prompts the adrenal glands to make hormones. They then measure a hormone called 17-hydroxyprogesterone in the blood. The team asked whether a sample at 30 minutes is as useful as one at 60 minutes.
Çiftci reviewed records for 150 patients aged up to 18 years tested between 2000 and 2024. Twenty-nine patients reached the diagnostic level, and three looked normal at 30 minutes but showed the clear result at 60 minutes. No case was found early that was missed later, so the later sample caught every case. The V281L gene variant was the most common cause found.
Catalog record
| CREATOR | Nurdan Çiftci, Emine Çamtosun, İsmail Dündar, Edip Ünal, Nurullah Çelik, Ayşehan Akıncı |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |