Probiotics in Combination with C16 Peptide and Angiopoietin-1 Synergistically Ameliorate Multiple Sclerosis in Mice
Qiang Li, Yi Zhao, Lu Bai, Lu-Ping Tang, Shu Han · 2026
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Description
Qiang Li and colleagues tested probiotics combined with a peptide growth factor compound against multiple sclerosis in mice in a 2026 study. The animal model was experimental autoimmune encephalomyelitis, which mimics the demyelination, axon loss, and neuronal injury of the human disease. Groups included control, vehicle, probiotics alone, and the combination of probiotics with C16 peptide plus angiopoietin-1, a pairing already shown to protect in this model.
Tissue examination, behavior tests, and stool gene sequencing measured brain and spinal cord inflammation, myelin loss, neuronal survival, gut microbes, and functional recovery. Combination treatment is presented as synergistic, pairing gut modulation with direct vessel and nerve protection. Mice were split by chance to each arm, so gaps in nerve harm or gut germs can be tied to the drugs with fair faith in the work.
Catalog record
| CREATOR | Qiang Li, Yi Zhao, Lu Bai, Lu-Ping Tang, Shu Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |