Transient receptor potential vanilloid 2 functions as a directional driver for hepoxilin A3–mediated neutrophil migration
Claudia Feriotti, Regino Mercado-Lubo, Merran Bryford, Rebecca Ferrisi, Francesca Gado, Clementina Manera, Keyi Liu, Ping Lu, Yushuan Lai, Beth A. McCormick, Randall Mrsny · 2026
Read Transient receptor potential vanilloid 2 functions as a directional driver for hepoxilin A3–mediated neutrophil migration by Claudia Feriotti, Regino Mercado-Lubo, Merran Bryford, Rebecca Ferrisi, Francesca Gado, Clementina Manera, Keyi Liu, Ping Lu, Yushuan Lai, Beth A. McCormick, Randall Mrsny (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13426407.txt.
Description
Feriotti and colleagues uncovered in 2026 how a fat-based signal called hepoxilin A3 pulls neutrophils across gut lining toward infection. These immune foot soldiers move under the control of a membrane channel, TRPV2, that passes calcium ions. Neutrophils must follow attracting signals yet heed stop signals, or they damage healthy tissue. The balance between the two was only partly mapped.
At rest, a cannabinoid receptor on the cell surface answers the body's own cannabis-like molecules and brakes migration, while a small share of TRPV2 channels sits ready. When hepoxilin appears, stored TRPV2 rushes to the cell's leading edge and pairs physically with the brake receptor, forming a guidance complex that keeps the cell on course. After firing, used TRPV2 is discarded while the brake receptor is recycled, a relay that preserves direction.
Catalog record
| CREATOR | Claudia Feriotti, Regino Mercado-Lubo, Merran Bryford, Rebecca Ferrisi, Francesca Gado, Clementina Manera, Keyi Liu, Ping Lu, Yushuan Lai, Beth A. McCormick, Randall Mrsny |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |