Programming angiogenesis with tunable assemblies of multifunctional peptides
Joseph Dodd-o, Bobak Shadpoor, Abhishek Roy, Roya Jafari, Tarunya R. Sudarshan, Abigail Holberton, Dongjing He, Francesco Coppola, Daniel M. Dinakarapandian, Deep Malu, Gelavizh Gharati, Alexandra Griffith, Harrison Rohe-Weiner, Siya Patel, Edward Bonder, Yuhang Hu, Levi Wood, Anant K. Paravastu, Petr Kral, Vivek A. Kumar · 2026
Read Programming angiogenesis with tunable assemblies of multifunctional peptides by Joseph Dodd-o, Bobak Shadpoor, Abhishek Roy, Roya Jafari, Tarunya R. Sudarshan, Abigail Holberton, Dongjing He, Francesco Coppola, Daniel M. Dinakarapandian, Deep Malu, Gelavizh Gharati, Alexandra Griffith, Harrison Rohe-Weiner, Siya Patel, Edward Bonder, Yuhang Hu, Levi Wood, Anant K. Paravastu, Petr Kral, Vivek A. Kumar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13426406.txt.
Description
Dodd-o and colleagues reported in 2026 on a peptide gel designed to grow new blood vessels where tissue needs better blood supply. Peptides are short chains of amino acids, and these ones join on their own into tiny fibres. One peptide mimics a growth signal called VEGF that tells vessel cells to multiply, while a second, stronger peptide gives the gel its structure and firmness.
Dodd-o tuned the gel stiffness across a wide range while keeping the signal peptide able to reach its receptor on vessel cells. Computer simulations and magnetic resonance tests showed the two parts pack closely without blocking the active signal. In cell tests the gels sped up vessel cell growth, and in mouse and rat implants they drew in new vessels that linked stably with the host tissue. The design offers a flexible platform for building healing materials.
Catalog record
| CREATOR | Joseph Dodd-o, Bobak Shadpoor, Abhishek Roy, Roya Jafari, Tarunya R. Sudarshan, Abigail Holberton, Dongjing He, Francesco Coppola, Daniel M. Dinakarapandian, Deep Malu, Gelavizh Gharati, Alexandra Griffith, Harrison Rohe-Weiner, Siya Patel, Edward Bonder, Yuhang Hu, Levi Wood, Anant K. Paravastu, Petr Kral, Vivek A. Kumar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |