A Rac-PI3Kβ feedback loop drives GPVI-dependent platelet activation
Tom.N. Durrant, James.L. Hutchinson, Carl.J. May, Justin.S. Trory, Samantha.F. Moore, Ingeborg Hers · 2026
Read A Rac-PI3Kβ feedback loop drives GPVI-dependent platelet activation by Tom.N. Durrant, James.L. Hutchinson, Carl.J. May, Justin.S. Trory, Samantha.F. Moore, Ingeborg Hers (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13426228.txt.
Description
Tom N. Durrant and coauthors define a feedback loop between Rac and PI3K-beta in platelet activation in a 2026 study. The collagen receptor GPVI triggers platelet responses partly through PI3K-beta, an enzyme unusual among its class because small GTPases such as Rac can switch it on. Knockin mice carrying two mutations in the Rho-binding domain of the enzyme's catalytic subunit showed impaired GPVI signaling, function, and spreading on fibrinogen.
A selective PI3K-beta inhibitor reproduced most defects, and blocking Rac or Cdc42 in normal platelets copied the knockin pattern. The loop helps explain how platelets build stable clots under high shear flow.
Catalog record
| CREATOR | Tom.N. Durrant, James.L. Hutchinson, Carl.J. May, Justin.S. Trory, Samantha.F. Moore, Ingeborg Hers |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60180 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |