Impaired Renal Base Excretion in Secretin Receptor Knock‐Out Mice During Prolonged Base‐Loading
Tobias Jensen, Jesper Frank Andersen, Laura Woidemann Trans, Ida Marie Modvig, Helga Vitzthum, Jens Juul Holst, Bolette Hartman, Samuel L Svendsen, Mads Vaarby Sørensen, Jens Leipziger, Peder Berg · 2026
Read Impaired Renal Base Excretion in Secretin Receptor Knock‐Out Mice During Prolonged Base‐Loading by Tobias Jensen, Jesper Frank Andersen, Laura Woidemann Trans, Ida Marie Modvig, Helga Vitzthum, Jens Juul Holst, Bolette Hartman, Samuel L Svendsen, Mads Vaarby Sørensen, Jens Leipziger, Peder Berg (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13426033.txt.
Description
Tobias Jensen and co-authors study kidney control of body acid in a 2026 mouse study. A gut hormone called secretin helps the kidney dump base when a sudden base load hits. It acts on a pump in the kidney's fine tubes that pushes base out into urine. Whether the same path serves during long base loads was not known.
The team gave mice with the hormone's sensor knocked out, and normal mice, base-rich water for up to eight days. Blood and urine acid tests tracked how each group coped. Mice without the sensor shed base poorly, and the pump's amount and work shifted as well.
Catalog record
| CREATOR | Tobias Jensen, Jesper Frank Andersen, Laura Woidemann Trans, Ida Marie Modvig, Helga Vitzthum, Jens Juul Holst, Bolette Hartman, Samuel L Svendsen, Mads Vaarby Sørensen, Jens Leipziger, Peder Berg |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |