Human Pharmacokinetic Prediction of Antibody‐Drug Conjugates Using Human FcRn Transgenic Mice
Keitaro Nakagawa, Kenta Haraya · 2026
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Description
Keitaro Nakagawa and co-authors test whether mice carrying the human FcRn receptor can predict how antibody-drug conjugates behave in people. These conjugates link an antibody to a toxic drug payload, and forecasting human pharmacokinetics, how the body absorbs and clears a drug, is difficult early in development. Their 2026 study uses a transgenic mouse model already trusted for antibody drugs.
Eight approved conjugates were given to the mice, and clearance values were calculated with a standard two-compartment model. Mouse clearance correlated strongly with known human clearance. Scaling from the mouse data alone, using an exponent of 1.0, placed 87.5 percent of the drugs within twofold of their true human clearance. The authors present single-species scaling from these mice as a promising early prediction tool.
Catalog record
| CREATOR | Keitaro Nakagawa, Kenta Haraya |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |