Translational boundaries of Txnip-targeted metabolic modulation in bone homeostasis
Zhewei Ma, Yiquan Ji · 2026
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Description
Zhewei Ma and Yiquan Ji wrote a 2026 commentary on the translational limits of targeting Txnip, the thioredoxin-interacting protein, to improve bone health. Work they discuss ties Txnip to coordination of glycolysis and the tricarboxylic acid cycle in bone, with altered levels linked to defective remodeling and slower fracture healing in older age. Blocking Txnip has been proposed alongside marrow stromal cell regeneration strategies.
Three gaps temper enthusiasm: which bone cell types drive the effect, how broadly metabolism shifts, and whether human tissue behaves like the models. The authors urge cell-specific testing before metabolic modulation enters bone therapy trials.
Catalog record
| CREATOR | Zhewei Ma, Yiquan Ji |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 6 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |