Preoperative Single-Fraction Versus Fractionated Stereotactic Radiation Therapy: A Single-Institutional Analysis of 299 Resected Metastases
Haley K. Perlow, Sydney Luu, Sohil Reddy, Jared Bradshaw, Sarah Hennings, Jennifer K. Matsui, Brett G. Klamer, Rituraj Upadhyay, Alexandria Oliver, John McGregor, Russell Lonser, Daniel Prevedello, James B. Elder, Kyle Wu, Roshan Prabhu, Simeng Zhu, Raj Singh, Sasha J. Beyer, John Grecula, Dukagjin M. Blakaj, Evan M. Thomas, Raju R. Raval, Joshua D. Palmer · 2026
Read Preoperative Single-Fraction Versus Fractionated Stereotactic Radiation Therapy: A Single-Institutional Analysis of 299 Resected Metastases by Haley K. Perlow, Sydney Luu, Sohil Reddy, Jared Bradshaw, Sarah Hennings, Jennifer K. Matsui, Brett G. Klamer, Rituraj Upadhyay, Alexandria Oliver, John McGregor, Russell Lonser, Daniel Prevedello, James B. Elder, Kyle Wu, Roshan Prabhu, Simeng Zhu, Raj Singh, Sasha J. Beyer, John Grecula, Dukagjin M. Blakaj, Evan M. Thomas, Raju R. Raval, Joshua D. Palmer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13425576.txt.
Description
Haley K. Perlow and coauthors analyzed preoperative radiation before surgery for brain metastases in a 2026 single-institution study of 299 resected lesions. Standard care has been resection followed by focused radiation, yet giving radiation first may lower radiation necrosis, local failure, and nodular meningeal disease. The team compared single-fraction treatment with fractionated stereotactic treatment delivered before resection.
Their hypothesis favors fractionation for reducing those three complications while keeping tumor control. Surgeons and radiation oncologists gain comparative data for large or symptomatic metastases where intracranial disease is otherwise limited and resection is planned. The work gives teams hard facts they can use when they weigh risk, gain, and cost at the time they plan care for each case. Each case was checked by hand, so the count rests on charts that staff read with care, not on codes pulled in bulk from a screen.
Catalog record
| CREATOR | Haley K. Perlow, Sydney Luu, Sohil Reddy, Jared Bradshaw, Sarah Hennings, Jennifer K. Matsui, Brett G. Klamer, Rituraj Upadhyay, Alexandria Oliver, John McGregor, Russell Lonser, Daniel Prevedello, James B. Elder, Kyle Wu, Roshan Prabhu, Simeng Zhu, Raj Singh, Sasha J. Beyer, John Grecula, Dukagjin M. Blakaj, Evan M. Thomas, Raju R. Raval, Joshua D. Palmer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28825 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |