Onset of Motor Complications and Medication Dose in Newly Diagnosed and Treated Parkinson’s Disease
Yasushi Osaki, Yukari Morita, Sho Ohtsuru, Tomohiro Shogase, Daiji Yoshimoto, Tatsuya Ikeda, Sayomi Kabeya, Yu Hashimoto, Takuya Matsushita, Suraiya Saleem · 2026
Read Onset of Motor Complications and Medication Dose in Newly Diagnosed and Treated Parkinson’s Disease by Yasushi Osaki, Yukari Morita, Sho Ohtsuru, Tomohiro Shogase, Daiji Yoshimoto, Tatsuya Ikeda, Sayomi Kabeya, Yu Hashimoto, Takuya Matsushita, Suraiya Saleem (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13424818.txt.
Description
Osaki and colleagues followed 120 people newly diagnosed with Parkinson's disease in 2026 to chart when motor complications appear after drug treatment begins, and at what doses. Two complications dominate long treatment: on-off swings, where the drug's effect fades between doses, and dyskinesias, involuntary movements. Knowing their timing helps doctors plan therapy.
Three in five patients developed a complication, with a middle time to onset of about twenty-eight months. On-off swings came first for most, while dyskinesias arrived later, at a middle of about fifty months and at higher drug doses. Doses at onset varied widely between patients, and the groups with the longest delay were taking the most drug, not the least. Five patients got dyskinesias before any on-off swings, and younger onset raised dyskinesia risk.
Catalog record
| CREATOR | Yasushi Osaki, Yukari Morita, Sho Ohtsuru, Tomohiro Shogase, Daiji Yoshimoto, Tatsuya Ikeda, Sayomi Kabeya, Yu Hashimoto, Takuya Matsushita, Suraiya Saleem |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |