Inflammation-Induced Temperature Shifts and Mitochondrial Function: Rethinking Biomarker Interpretation in Depressive Disorders
Alexander Karabatsiakis, Rafael Pfeiffer, Annalena Steinlechner, Karin de Punder · 2026
Read Inflammation-Induced Temperature Shifts and Mitochondrial Function: Rethinking Biomarker Interpretation in Depressive Disorders by Alexander Karabatsiakis, Rafael Pfeiffer, Annalena Steinlechner, Karin de Punder (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13423309.txt.
Description
Alexander Karabatsiakis and three co-authors argue that inflammation-driven temperature shifts and mitochondrial function should change how biomarkers for depression are read. Depression impairs mood, thinking, and body function, and it raises long-term risk of immune, heart, metabolic, and brain diseases, yet clinicians still lack markers that can guide diagnosis or prevention.
Decades of work, the authors note, have mapped several interacting systems in depression, including hormone and brain pathways, without yielding a direct clinical test. Their piece reframes two overlooked signals: body temperature changes driven by inflammation, and the energy-producing mitochondria. Reading such markers without that context, they suggest, may explain why promising candidates keep failing in practice.
Catalog record
| CREATOR | Alexander Karabatsiakis, Rafael Pfeiffer, Annalena Steinlechner, Karin de Punder |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8764 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |