Myosin VI drives breast cancer progression via SP1/CA9-mediated acidic tumor microenvironment remodeling and subsequent M2 macrophage polarization
Fang Liu, Ziyang Li, Guopeng Zeng, Shuting Yang, Ying Zhao, Fengbei Li, Zihan Yu, Zhirou Li, Jueyu Zhou · 2026
Read Myosin VI drives breast cancer progression via SP1/CA9-mediated acidic tumor microenvironment remodeling and subsequent M2 macrophage polarization by Fang Liu, Ziyang Li, Guopeng Zeng, Shuting Yang, Ying Zhao, Fengbei Li, Zihan Yu, Zhirou Li, Jueyu Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13423164.txt.
Description
Liu and colleagues show in 2026 how myosin VI helps breast cancer turn its surroundings acidic and disarm immune attack. Myosin VI is a motor protein that hauls cargo inside cells. Acidic surroundings are known to suppress immunity, but this driver's role was not.
Analyzing large cancer datasets, the team linked high myosin VI levels to more M2 macrophages, a wound-healing immune state that shelters tumors, and to poorer patient outcomes. Inside the cell nucleus, the protein recruits the factor SP1 and the gene-reading machinery to switch on CA9, an enzyme that pumps acid outward. The acid then triggers a sensor on macrophages that flips them into the M2 state. A drug blocking myosin VI reduced acidification in mice, revived antitumor immunity, and made anti-PD-L1 immunotherapy work better.
Catalog record
| CREATOR | Fang Liu, Ziyang Li, Guopeng Zeng, Shuting Yang, Ying Zhao, Fengbei Li, Zihan Yu, Zhirou Li, Jueyu Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |