Estimation of persistent inward currents contribution to inspiratory motoneuron firing in humans
Ricardo N O Mesquita, Simon C Gandevia, Janet L Taylor, Anna L Hudson, Jane E Butler · 2026
Read Estimation of persistent inward currents contribution to inspiratory motoneuron firing in humans by Ricardo N O Mesquita, Simon C Gandevia, Janet L Taylor, Anna L Hudson, Jane E Butler (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13423127.txt.
Description
Ricardo N O Mesquita and four colleagues ask whether persistent inward currents, electrical boosts that prolong nerve cell firing, help drive the human breathing muscles. Such currents are well shown in limb muscles, and their channels appear in breathing motor neurons, but a direct role in human inspiration had not been tested.
Fine-wire recordings captured single motor units in the diaphragm and in chest-wall muscles during quiet and guided breathing in small groups of volunteers. Only diaphragm units showed the firing pattern that signals a likely current contribution, and diaphragm units also kept firing into exhalation more often than most chest muscles. Guided breathing changed firing symmetry in some chest muscles without changing the current estimate, hinting the mechanism differs by muscle.
Catalog record
| CREATOR | Ricardo N O Mesquita, Simon C Gandevia, Janet L Taylor, Anna L Hudson, Jane E Butler |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67225 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |